LMTK2 and Familial prostate cancer: We also noted an effect of genotype at the LMTK2 variant rs6465657, identified in the GWAS as a susceptibility factor for prostate cancer whereby individuals carrying two alleles of the protective 'T' allele allelic status expressed almost a third less LMTK2 than did individuals carrying one or more 'C' alleles (P = 0.002).