An endogenous TRPM7-like Mg2+-nucleotide-regulated metal current (MagNuM) and magnesium-inhibited cation (MIC) channel have been described in multiple cell types including RBL-2H3 cells, human retinoblastoma cells, cardiomycytes, glia, as well as neurons [1], [31], [32], [33], [34], [35]. This evidence concerns the gene TRPM7 and retinoblastoma.