KNG1 and type 1 diabetes mellitus: In addition to the phenotypic differences between CAC and BKmig, culture conditions might be harsher than the environment within the T1D patients, explaining that BK apparently induced pro-oxidative signaling in HG-cultured cells – which is reduced by receptor blockade – while in the T1D patients' BKmig cells, kinin receptor blockade led to an increase in oxidative stress, indicating rather anti-oxidant effects of BK.