BKmig derived from H PBMC generated NO in response to BK stimulation through a mechanism involving both kinin receptors (being similarly blunted by B1R antagonist LdA-BK and B2R antagonist icatibant) and eNOS (being totally blocked by L-NIO), while T1D BKmig did not (Fig. 7A). This evidence concerns the gene BDKRB1 and type 1 diabetes mellitus.