The fascin expression level in epithelial cells is usually low, however it is often upregulated and overexpressed in transformed cells and in several types of human neoplasm, including breast [15,16], ovary [17], skin [18], pancreas and liver [19-21], non-small cell lung carcinomas, lung carcinoids [22,23], stomach and esophageal squamous cell carcinoma [18,24,25]. This evidence concerns the gene FSCN1 and esophageal squamous cell carcinoma.