When we compared mean nocturnal levels (mean of 18:00h-22:00h-02:00h) cortisol (p = 0.02), TRH (p = 0.03), GH (p < 0.01), CD16 (p < 0.0001) and CD25 (p = 0.03) levels were higher in cancer patients, whereas melatonin (p = 0.04), TSH (p = 0.02), IGF-1 (p < 0.0001), CD8 (p = 0.01), CD8bright (p = 0.001), CD20 (p = 0.03), TcRδ1 (p = 0.001) and δTcS1 (p = 0.02) levels were lower in cancer patients. This evidence concerns the gene IGF1 and cancer.