The set of 303 genes which were upregulated in CAD patients was enriched for genes with nucleic acid binding properties and 11 genes involved in the "MAPKKK cascade", including MAP3K12/MUK, MAPK11/p38 beta, MAPK12/p38-gamma, and MAPK7/ERK5 and 60 genes involved in "Nucleoside, nucleotide and nucleic acid metabolism", including transcription factors, DNA- and RNA helicases, RNA polymerases and mRNA splicing factors, suggesting a higher transcriptional activity. This evidence concerns the gene MAPK12 and coronary artery disorder.