As pre-treatment with Tanshinone IIA reduces TNF-α, the myeloperoxidase (MPO) marker of leukocytes, E-selectin and ICAM-1 in ischemic brain tissue and serum IL-8, Danshen may inhibit inflammatory responses to reduce brain damage induced by ischemia-reperfusion injury in rats [41]. The gene discussed is MPO; the disease is ischemia reperfusion injury.