TP53 and neoplasm: CGH-based lineage analysis of another subset of poorly differentiated advanced GCs with tubular components but no layered structure in the mucosal part revealed that GCs of this subset were derived from a tubular component in a tumour and were characterized by 17p- and 8q+ [16] and inactivation of the wild-type TP53 by mutation and loss of heterozygosity (LOH) [17].