A pattern of MYC+ and/or TP53- was detected in 3 of the 13 intramucosal cancers, none of the 9 mucosal samples of invasive TUBs, 1 of the 3 invasive samples of 3 submucosal cancers and 5 of the 6 invasive samples of 6 advanced cancers. This evidence concerns the gene TP53 and cancer.