Among the early cancers examined in the present study, an invasive part of 1 tumour (#S3) and 3 intramucosal cancers (#M11, #M12 and #M13) showed the signature of aggressive cancer (MYC+ and/or TP53-) and frequent mutations of TP53; however, in 1 submucosal cancer (#S1), the invasive parts showed the signature of dormant cancer (MYC-/TP53+). Here, TP53 is linked to neoplasm.