Mutations were detected in 7 of the tumours that were examined for sequence analysis of exons 5-8 of TP53 (Figure 1, Table 3): 1 of the 10 intramucosal cancers, 2 of the 3 submucosal cancers and all 4 advanced cancers (only the invasive parts). This evidence concerns the gene TP53 and neoplasm.