Because of the functions of both DARPP-32 and NCS-1 in dopaminergic signaling, the main target of antipsychotics, and their alterations in PFC of schizophrenia patients, we studied the effects of typical and atypical antipsychotics in expression of DARPP-32 and NCS-1 in five regions of rat's brain: prefrontal cortex, hippocampus, striatum, cortex and cerebellum. The gene discussed is NCS1; the disease is schizophrenia.