In the context of developing information on the potential involvement of the IL1 gene cluster in POAG, we aimed to investigate the role of this genomic region using the well-studied three SNPs (IL1A -889C/T, IL1B -511C/T, IL1B +3953C/T) (Figure 1) in eastern Indian patient cohort. The gene discussed is IL1A; the disease is open-angle glaucoma.