These genes are enriched in several cancer-related functional clusters, including insulin-like growth factor binding (Htra3, Igfbp5, Cyr61, Wisp1), GTP binding (Tubb6, Tgtp, Rnd1, Gbp1, Rab40b, Gbp2, Rhobtb1, Rabl3, Gbp3), cytokine activity (Clcf1, Kitl, Socs2, Cxcl5, Tnfsf11, Cxcl1, Cx3cl1, Il12a) and negative regulation of apoptosis (Cln8, Clcf1, Nuak2, Kitl, Dlx1, Notch1, Bcl2, Serpinb9, Clec2 d, Nr4a1, Fastkd2, Rassf5, Elmo1) (see Additional file 3 for complete listing of genes). Here, RASSF5 is linked to cancer.