These genes are enriched in several cancer-related functional clusters, including insulin-like growth factor binding (Htra3, Igfbp5, Cyr61, Wisp1), GTP binding (Tubb6, Tgtp, Rnd1, Gbp1, Rab40b, Gbp2, Rhobtb1, Rabl3, Gbp3), cytokine activity (Clcf1, Kitl, Socs2, Cxcl5, Tnfsf11, Cxcl1, Cx3cl1, Il12a) and negative regulation of apoptosis (Cln8, Clcf1, Nuak2, Kitl, Dlx1, Notch1, Bcl2, Serpinb9, Clec2 d, Nr4a1, Fastkd2, Rassf5, Elmo1) (see Additional file 3 for complete listing of genes). The gene discussed is RHOBTB1; the disease is cancer.