Previously, evolutionarily conserved zinc finger transcription factor binding sites recognized by WT1, EGR1, SP1, SP2, AP2 and GATA1 were identified in the promoters of 24 differentially expressed prostate cancer genes from eight mammalian species [26], suggesting these zinc finger proteins play a pivotal role in the prostate. The gene discussed is ZNF146; the disease is Familial prostate cancer.