For a K of 4, we again found three clusters associated with lumA (P = 2 × 10-6), lumB (P = 2 × 10-6) and basal-like (P = 3 × 10-20) tumours, respectively, whereas the remaining cluster was the smallest (11% of tumours) and contained a mixture of subtypes. This evidence concerns the gene TMEM43 and neoplasm.