Recently, we have shown that the transmembrane mucin protein MUC1 is an endogenous ligand of galectin-3 in human colon cancer cells and that the interaction between MUC1 and galectin-3 occurs via binding of galectin-3 to the oncofetal Thomsen-Friedenreich carbohydrate (Galβ1,3GalNAcα-, T or TF) antigen on MUC1 [12]. The gene discussed is LGALS3; the disease is colonic neoplasm.