As change of MUC1 cell surface localization in response to galectin-3 binding may also expose the adhesion molecules that are essential to homotypic cancer cell interactions, we hypothesised that an increased interaction between circulating galectin-3 and cancer-associated MUC1 expressed on the surface of circulating tumour cells in cancer patients may promote the formation of cancer cell aggregates/emboli thus prolongs the survival of disseminated tumour cells in the circulation and contributes to cancer cell haematogenous dissemination. The gene discussed is MUC1; the disease is neoplasm.