CIN is associated with a series of genetic changes that involve the activation of oncogenes as KRAS and inactivation of tumor suppressor genes as TP53, SMAD4/DPC4 and APC, while as MIN is associated with mutations in DNA mismatch repair (MMR) genes which affect DNA replication in repetitive sequences (microsatellites), resulting in an accumulation of frameshift mutations in genes that contain microsatellites [4-6]. This evidence concerns the gene SMAD4 and cervical squamous intraepithelial neoplasia.