In peripheral tumor tissues, VEGFR-3 expressions were significantly correlated rather with VEGF-C high expression (P < 0.000), VEGF-D high expression (P = 0.043), increased P-LVD (P < 0.001) and the presence of LVI (P = 0.003), than with VEGF-A expression, increased I-LVD, venous invasion and lymph node metastasis (P > 0.05). This evidence concerns the gene FLT4 and metastatic malignant neoplasm in the lymph nodes.