No correlations was found between I-LVD and VEGFs expressions, while P-LVD was significantly correlated with larger tumor size (P < 0.001), depth of invasion (P = 0.026), lymph node metastasis (P < 0.001), LVI (P < 0.001), venous invasion (VI) (P < 0.001), TNM stage (P < 0.001), VEGF-C (P = 0.003) and VEGF-D expression (P = 0.005). Here, VEGFD is linked to metastatic malignant neoplasm in the lymph nodes.