In gastric cancer, VEGF-A and VEGF-C may play the distinct role: VEGF-A is more likely to be associated with haematogenous metastasis, while VEGF-C is indictive of lymphatic metastasis [28].Other report showed the increased expression of VEGF-A as well as VEGF-C expression is essential in lymph node metastasis [29].VEGF-A stimulates the tumor angiogenesis through activation of VEGFR-1 and VEGFR-2. This evidence concerns the gene VEGFA and neoplasm.