At 20 wks gestation RLX-2:TIMP-2 ratio ≤ 0.05 was best associated with a history of RPL [sensitivity 67%, specificity 80%, LR+ 3.3 95% CI 2.1 - 5.4, LR- 0.42 95% C1 0.1 - 1.5, P < 0.001), Table 2] Among women with RPL serum MMP and TIMP levels did not differ by cause of miscarriage or by treatment with aspirin or LMWH (data not shown). Here, TIMP1 is linked to Miscarriage.