Supporting the role of IL-17 in Th2 cell-mediated and eosinophilic inflammation in asthma, our recent study has shown that inhibition of IL-17 activity with anti-IL-17 Ab reduces remarkably allergen-induced airway infiltration of inflammatory cells including eosinophils, Th2 cytokine levels in BAL fluids, and AHR [68]. The gene discussed is AHR; the disease is asthma.