In this study, the degree of the expression of SPARC showed that 81 cases (71.1%) with low reactivity and 33 cases (28.9%) with high reactivity in tumor cells, 61 cases (53.5%) with low reactivity and 53 cases (46.5%) with high reactivity in the MSC surrounding the tumor, and 84 cases (73.7%) with low reactivity and 30 cases (26.3%) with high reactivity in the normal colon mucosa tissue, respectively. This evidence concerns the gene SPARC and neoplasm.