SPARC and neoplasm: SPARC expression in colon cancer cells was no significant difference determined with clinicopathological parameters (P > 0.05), but SPARC expression in MSC was (1) significantly negative related to the differentiation of tumor (P < 0.05, r = -0.175); (2) statistically significant difference with lymph node metastasis (P < 0.05); and (3) no significant difference with the patients age, sex, tumor size, tumor location, lymphatic infiltration, and TNM staging (P > 0.05) (Table 2).