Promoter methylation changes of p16INK4a, p15INK4b, and Sfn have been reported in CC (Lee et al. 2002; Yang et al. 2005), and hypomethylation-induced Myc overexpression has been found in various types of tumors (Del Senno et al. 1989; Tao et al. 2002; Tsujiuchi et al. 1999). This evidence concerns the gene MYC and cholangiocarcinoma.