RUBCN and Alzheimer disease: It will be important do determine if other proteins that are part of the BECN1 complex (Atg14L, PIK3R4, UVRAG, Ambra1, Vps15, Bif-1, or Rubicon) are also reduced in AD or in response to BECN1 reduction, respectively, as this could help explain the (possibly indirect) effects of BECN1 reduction on autophagosomal degradation (Fig. 8).