Moreover, statistically significant associations were found between gene amplification and protein expression for both HER-2 and TOPOIIα, between HER-2 and TOPOIIα gene amplification and between HER-2 and TOPOIIα protein expression, confirming the results of previous studies regarding pancreatic and gastric cancers.2,4 Chromosome 17 aneusomy was found to be associated with TOPOIIα protein overexpression but not with each gene amplification. This evidence concerns the gene ERBB2 and gastric cancer.