α2M expression was decreased to 2.3-fold in male and 1.8-fold in female WD patients (p<0.001), C3 to 1.8-fold in male and 1.9 in female (p<0.005) and FB to 2.4-fold in male and 1.6-fold in female (p<0.005). This evidence concerns the gene A2M and Wilson disease.