Here, we aimed to consolidate all available data on two SNPs independently associated with autoimmunity within the KIAA1109-TENR-IL2-IL21 gene cluster: rs6822844 (minor allele protective) and rs17388568 (minor allele susceptible), each into a single meta-analysis of association with RA that included previously published data, new genotype data from Australasia, and publicly-available data from the Wellcome Trust Case Control Consortium (WTCCC) [22]. This evidence concerns the gene IL21 and rheumatoid arthritis.