Here we have combined published studies testing association of two SNPs, rs6822844 and rs17388568, located within the KIAA1109-TENR-IL2-IL21 region with RA: the former with two Dutch [6,21], one UK [12], and one Western Europe sample set [20]; and the latter with one UK sample set [12] - along with new Australasian data, and data from the WTCCC [22]. The gene discussed is IL21; the disease is rheumatoid arthritis.