What will be important in understanding molecular control of autoimmunity will be association studies in large sample sets from different autoimmune phenotypes that comprehensively capture common variation in the IL23R and KIAA1109-TENR-IL2-IL21 loci, fine-mapping of the genetic effects and analysis of interaction between the disease-associated variants, both within and between loci. The gene discussed is IL2; the disease is Autoimmunity.