Including the HLA region and the 10 loci confirmed by Stahl et al. [30] (note that Stahl et al. did not confirm KIAA1109-TENR-IL2-IL21 at a genome-wide level of significance), KIAA1109-TENR-IL2-IL21 is the 20th locus associated with RA at a genome-wide level of significance (P ≤ 5 × 10-8). The gene discussed is IL21; the disease is rheumatoid arthritis.