Genotyping of an Australasian RA case-control sample set, and meta-analysis with published and publicly-available data confirm at a genome-wide level of significance the rs6822844 SNP within the KIAA1109-TENR-IL2-IL21 locus to be a risk factor in RA (P = 2.1 × 10-8; OR = 0.86). Here, IL21 is linked to rheumatoid arthritis.