We examined rs6822844, rs17388568 and rs907715. The latter SNP was chosen because it had been associated with risk of the systemic autoimmunity SLE in a single study [17] (OR = 0.78, P = 0.002), was in weak LD with both rs6822844 and rs17388568 and we hypothesized that it could represent a possible third effect within the KIAA1109-TENR-IL2-IL21 cluster, perhaps specific to systemic autoimmunity. Here, IL21 is linked to systemic lupus erythematosus.