Genetic association studies so far, have focussed on trachoma scarring or trachomatous trichiasis and human polymorphisms within loci involved in immunity and inflammation [13] and include several within the TNF locus including the -308G-A TNF-α promoter single nucleotide polymorphism (SNP) [14], [15]; the -1082A-G IL-10 SNP [16], [17]; chemokine and cytokine clusters in chromosomes 4q & 5q31 and HLA class I alleles [18], reviewed in [12]. This evidence concerns the gene TNF and Trichiasis.