MAP2K7 and permanent neonatal diabetes mellitus-pancreatic and cerebellar agenesis syndrome: Immunohistochemistry of PaCa tissues showed that two target phosphoproteins, p-ERK and p-MEK, were simultaneously well expressed during the early stage neoplasms, even in the cancer cells of non-invasive or minimally invasive ductal carcinoma, as well as in the advanced stage patients with PaCa.