APOA1 and cancer: Although this proteomic response is novel in the context of oesophageal cancer, apolipoprotein A-I has previously been reported as a serum marker for the detection of cancer, with a reduction in breast (Huang et al, 2006), pancreatic (Ehmann et al, 2007) and colorectal (Engwegen et al, 2006) cancers when compared with healthy controls.