The molecular hallmark of BL is the activation of the c-myc oncogene through reciprocal chromosomal translocations that juxtapose c-myc on chromosome 8 to the immunoglobulin (Ig) heavy chain locus on chromosome 14 (80% of cases) or the κ- or λ-light chain locus on chromosome 2 (10% of cases; Aldoss et al, 2008). The gene discussed is MYC; the disease is Burkitt lymphoma.