MTHFR and malignant colon neoplasm: Those with the MTHFR 1298 A/C genotype had a tendency toward higher risk of colon cancer than did those with the 1298 A/A genotype (1.50; 0.89–2.53), whereas those with the MTHFR 1298 C/C genotype had a tendency for decreased risk, as compared with patients with the 1298 A/A genotype (0.65; 0.11–3.70).