Only one SNP rs10946398 among the three SNPs we typed in CDKAL1 showed a significant association with T2D in this study, however this SNP showed to have the most significant association with T2D in all three models (multiplicative, dominant and recessive models) being tested among all nineteen SNPs we typed, indicating that the CDKAL1 gene may contribute more than the other three T2D-related genes in the development of T2D in Chinese patients being studied. Here, CDKAL1 is linked to type 2 diabetes mellitus.