For example, genetic variants in more than 15 genes/loci including CDKN2A/B, CDKAL1, SLC30A8, IGF2BP2, HHEX/IDE, FTO, KCN1, NOTCH2, CDC123/CAMK1D, ADAMTS9, THADA, TSPAN8/LGR5, JAZF1, MTNR1B and IRS genes, have been showed to be associated with T2D by genome-wide association studies (GWAS) [10-19]. This evidence concerns the gene HHEX and type 2 diabetes mellitus.