Moreover, in an updated report on 272 patients treated with IL-2–based therapy at the National Institutes of Health, no significant association between HLA type and response was observed.12 However, in other immune strategies for melanoma such as polyvalent melanoma, cell vaccine OS after treatment correlated with HLA phenotypes.29 However, it is important to mention that both resolution and reliability of molecular HLA typing has substantially improved during the last decade, which has led to partial revisions in HLA associations. Here, IL2 is linked to melanoma.