HLA-DRB1 and melanoma: Furthermore, because an increased risk of developing disease recurrence as well as second primary melanomas in melanoma patients presenting with localized disease has been associated with HLA-DQB1*0301 or HLA-DRB1*1101 alleles,13-16 we compared the frequency of these genotypes in 2 groups of melanoma patients defined by outcome—namely, those who remained free of recurrence and those who have experienced disease recurrence.