RNA-mediated pathogenesis is believed to play a critical role in several other repeat expansion disorders, including Myotonic Dystrophy Type 1 (DM1) and Type 2 (DM2), SCA8, SCA12, Huntington's disease like 2 (HDL2), and fragile X tremor ataxias syndrome (FXTAS) [7], [8]. The gene discussed is PPP2R2B; the disease is myotonic dystrophy type 1.