Similar to observations made in most mouse adrenal tumour models, with age, adrenal glands of AdKO mice accumulated subcapsular Gata-4-positive spindle-shaped cells that are supposed to descend from multipotent progenitors capable to engage toward adrenal or gonadal fates [15], [55], [56]. The gene discussed is GATA4; the disease is adrenal gland neoplasm.