CD69 and autoimmune disease: Although the effect of LI on the CD69 expression was moderate, this fact could be hypothetically interpreted as beneficial, given that increased level of CD69 expression on T cells has been associated with some autoimmune diseases.[22, 24] Licorice has multiple constituents and not one active ingredient; therefore, it is possible that they are able to act in a regulatory way, both activating and modulating the immune response.