CCL2 and fibrosis: In line, hepatic mRNA expression of the chemokines ccl2 (F0-1 compared to F4 fibrosis, p = 0.0088) and ccl5 (F0-1 compared to F4 fibrosis, p<0.0001), but not of ccl3, was strongly up-regulated in fibrosis (Fig. 5C).