LHB and major depressive disorder: Moreover, the raphe nuclei are implicated in major depression, an illness which can be precipitated or exacerbated by disruptions of circadian alignment through jet lag or shift work (American Psychiatric Association, 2000; Monteleone and Maj, 2008), and an expanding body of evidence highlights the functional importance of raphe-LHb pathways in major depression (Sartorius et al., 2010; Sartorius and Henn, 2007; Yang et al., 2008).