Therefore, we compared the effects of RMs in the presence of hypovolemia, normovolemia, and hypervolemia on arterial blood gases, static lung elastance (Est,L), histology (light and electron microscopy), lung wet-to-dry (W/D) ratio, IL-6, IL-1β, caspase-3, type III procollagen (PCIII), intercellular adhesion molecule 1 (ICAM-1), and vascular cell adhesion molecule 1 (VCAM-1) mRNA expressions in lung tissue, as well as lung and distal organ epithelial cell apoptosis in an experimental model of sepsis-induced ALI. Here, VCAM1 is linked to Sepsis.