Figure 2 shows the expression of hBD-3 in the CIS lesion (Figure 2A and 2B) and co-stained CD68 and CCR2 accumulating in the CIS site, but not in the apparently normal region adjacent to the lesion (Figure 2C; the enlarged inset on the left, normal region adjacent to the CIS; on the right, CIS lesion, white arrowheads indicate CCF2+ macrophages), suggesting the association of the hBD-3-rich tumor microenvironment with recruitment of CCR2+ macrophages. Here, CCR2 is linked to neoplasm.