In the case of the breast carcinoma cell lines MCF-7_wt/_ADR, the methylation status of CGIs associated with the genes ABCB1, BRCA1, CDH1, DNAJC15, ESR1, GSTP1, PLAU, SULF2 and TGM2 was connected to the expression of the genes. This evidence concerns the gene BRCA1 and breast carcinoma.