Furthermore, findings of diminished Ser473 phosphorylation and/or activity in post-mortem brains of patients with schizophrenia [10] and depression [11] potentially fortify the association between dysregulation of mTORC2-Akt signaling and development of psychiatric illnesses, although these findings may be confounded by perimortem artifacts [12]. Here, AKT1 is linked to schizophrenia.