mTORC2/Akt signaling also provides a promising portal into “multiple hit” models of schizophrenia, as Akt is positioned to interact with other candidate genes such as neuregulin-1 and COMT [3],[49] as well as environmental risk factors for schizophrenia including obstetric complications and early life stressors [8],[50]. Here, COMT is linked to schizophrenia.