Consistent with a previous study on combined use of agonistic anti-4-1BB with adoptive T cell therapy [27], agonistic anti-4-1BB antibodies provided additional effects over and above the reactivated memory cells, largely preventing relapse and resulting in 80% cure of the 8-day pre-established tumor (Fig. 4A); in contrast, the rat IgG control had no effect over and above the T cells alone. This evidence concerns the gene TNFRSF9 and neoplasm.