Using HEK293 cells and human cervical carcinoma HeLaS3 cells, Yamamoto et al. [29] reported that LRP6 is internalized via the caveolae-mediated endocytic pathway, which is required not only for Wnt-3a-induced internalization of LRP6, but also for the accumulation of β-catenin. This evidence concerns the gene WNT3A and cervical carcinoma.