Examples of strongly down-regulated genes included IL6 (Entrez Gene 3569), IL8 (Entrez Gene 3576), IL1B (Entrez Gene 3553), CCL2/MCP1 (Entrez Gene 6347), SOCS3 (Entrez Gene 9021), HIF1A (Entrez Gene 3091), PTGS2/COX-2 (Entrez Gene 5743) and NAMPT/VISFATIN (Entrez Gene 10135) (Table S2), which have previously been described in the context of obesity. Here, IL6 is linked to obesity due to melanocortin 4 receptor deficiency.