Kurozumi et al. [146] found that single doses of the angiostatic and anti-inflammatory cyclic peptide of arginine-glycine-aspartic (cRGD), given before an oncolytic HSV, resulted in reduced tumor vessel permeability, leukocyte infiltration and IFN-γ, leading to increased survival of rats with intracranial gliomas. The gene discussed is IFNG; the disease is neoplasm.