IFNG and neoplasm: A recent finding by Ikeda et al. [75] suggested that the replication-selective Ad OBP-301, in which the E1 genes are under the control of the hTERT promoter, could stimulate peripheral blood mononuclear cells (PBMCs) to produce IFN-γ that has anti-angiogenic properties, resulting in reduced tumor vascularity and slowed growth in immunocompetent mice.