Some of the most significantly activated canonical pathways included hepatic fibrosis/hepatic stellate cell activation (CD14, COL1A1, FGFR2, IGFBP3, MMP2, and TGFBR1), and p38 MAPK signaling pathways (CREB1, PLA2G2A, TGFBR1). This evidence concerns the gene IGFBP3 and fibrosis.