For example, LUM, CCNA2, IGFBP3, HPX, COL1A1, SRPX, VIM, TGFBR1, DCN, MMP2, CD14, DCK, BIRC3, GJA1, LOX, SP100, PROM1 and CREB1 were known to regulate tumorigenesis, neoplasia, apoptosis, growth, differentiation and proliferation. This evidence concerns the gene CREB1 and neoplasm.