Over 70% of the conserved genes were associated with cancer according to the IPA knowledgebase, including LGALS3BP[50,51], VIM[52,53], DCN[54,55], IGFBP3[56], FGFR2[57], GJA1[58], SP100[59], DPP4[60], PROM1[61], BIRC3[62], MMP2[63], and COL1A1[64,65] (Table 2). The gene discussed is IGFBP3; the disease is cancer.