For example, LUM, CCNA2, IGFBP3, HPX, COL1A1, SRPX, VIM, TGFBR1, DCN, MMP2, CD14, DCK, BIRC3, GJA1, LOX, SP100, PROM1 and CREB1 were known to regulate tumorigenesis, neoplasia, apoptosis, growth, differentiation and proliferation. The gene discussed is LUM; the disease is neoplasm.