Although there have been several reports that have described an association between hypoxia-related genes and SUVmax in patients with lung cancer [17,18], this is the first study that has evaluated the impact of SLC2A1 gene polymorphisms on FDG-uptake in conjunction with the HIF-1a-activated transcription pathway in patients with NSCLC. The gene discussed is SLC2A1; the disease is non-small cell lung carcinoma.