CDH1 and neoplasm: Among these genes, snail acts as a transcriptional factor to repress genes that encode the cell-cell junctional apparatus, such as E-cadherin and occludin; and to enhance genes that encode mesenchymal or tumor interstitial components, such as fibronectin and vimentin, resulting in a dedifferentiated mesenchymal transition characterized by increased cell motility [4,5].