Pharmacological inhibition of GSK3 attenuates survival, proliferation and induce apoptosis [162,163,175]Active GSK3β promotes growth [176]Absence of inactive GSK3β (lower pSer9GSK3β expression) in tumors [88]High level expression and nuclear accumulation association with kinase activity and tumor dedifferentiation [161,177,178]. The gene discussed is GSK3B; the disease is neoplasm.