The fact that we did not find any association with abnormal cytology, HSIL and high risk HPV infection in the control group but found a susceptible effect with cervical cancer suggests that CCR2-64I variant is not associated with susceptibility to HPV infection and pre-cancerous lesions in our population but increases the risk of ICC at a later stage during the development of cancer of the cervix from HSIL (Figure 2). The gene discussed is CCR2; the disease is intrahepatic cholangiocarcinoma.