Although there are few reports on receptor tyrosine kinase signaling in uterine leiomyoma cells [14,32,33]), one study has shown that treatment of leiomyoma cells with 17-β estradiol results in enhanced secretion of PDGF, leading to the activation of the MAPK pathway and cell proliferation [32]. This evidence concerns the gene NTRK1 and Uterine leiomyoma.