Data from previous studies in our laboratory have shown increased levels of phosphorylated MAPK in uterine leiomyoma compared to matched myometrial tissue and in UtLM cells following treatment with IGF-I, and that IGF-I receptor signaling in leiomyoma tissue is through MAPKp44/42 [14]. The gene discussed is IGF1; the disease is uterine corpus leiomyoma.