NOD2 and Crohn disease: For a quantification of the CTLA4 association stratified by the above NOD2 and IL23R polymorphisms see Table 4 a Table 5: the minor alleles of the CT60, JO31 and JO27-1 within the CTLA4 modified the risk of Crohn's disease in the stratum of subjects carrying the frameshift insertion p.Leu1007fsX1008 in NOD2, while no perceivable effect of CTLA4 was found in the stratum of p.Leu1007fsX1008 wild-type homozygotes.